Gamma-Glutamyl Transferase: A Novel Cardiovascular Risk BioMarker
نویسندگان
چکیده
منابع مشابه
Gamma-glutamyl transferase: a novel cardiovascular risk biomarker.
Gamma-glutamyl transferase (GGT) is a second-generation enzymatic liver function test available for several decades, initially used as a sensitive indicator of alcohol ingestion, hepatic inflammation, fatty liver disease, and hepatitis. Longitudinal and cross-sectional investigational studies since 1990 have associated GGT with an increase in all-cause mortality, as well as chronic heart diseas...
متن کاملGamma-glutamyl transferase and metabolic risk factors for cardiovascular disease.
OBJECTIVE To elucidate the mechanism of the reported association between serum gamma-glutamyl transferase (GGT) activity and cardiovascular mortality. METHODS Cross-sectional analysis of the relationship between serum GGT activity and the risk factors for cardiovascular disease was performed. PATIENTS AND MATERIALS Middle-aged Japanese male personnel of the Self-Defense Forces who underwent...
متن کاملGamma glutamyl transferase.
Serum gamma-glutamyl transferase (GGT) has been widely used as an index of liver dysfunction and marker of alcohol intake. The last few years have seen improvements in these areas and advances in understanding of its physiological role in counteracting oxidative stress by breaking down extracellular glutathione and making its component amino acids available to the cells. Conditions that increas...
متن کاملSerum gamma-glutamyl transferase: A novel biomarker for coronary artery disease
BACKGROUND Atherosclerosis is a chronic inflammatory process, in which oxidative stress is the key event. Gamma-glutamyl transferase (GGT) is a cellular production of oxidants. We aimed to elucidate the relationship of serum GGT levels and coronary artery disease (CAD) in a Chinese population. MATERIAL AND METHODS A total of 513 adult subjects who had undergone coronary angiography were enrol...
متن کاملGamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study.
OBJECTIVE To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP). METHODS AND RESULTS In 3451 Framingham Study participants (mean age 44 years, 52% women) we examined the relations of GGT with CVD risk factors, and prospectively determined ...
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ژورنال
عنوان ژورنال: Preventive Cardiology
سال: 2010
ISSN: 1520-037X,1751-7141
DOI: 10.1111/j.1751-7141.2009.00054.x